Almost every year for the past decade, a Chinese Crested has won the World’s Ugliest Dog Contest in Petaluma, California. This year was no exception.
The 2012 winner, crowned on June 22, is eight-year-old Mugly, a bald and beady-eyed Chinese Crested who sports stringy whiskers weirdly reminiscent of dental floss.
Scientists have now found the secret recipe behind the spectacular variety of dog shapes and sizes, and it could help unravel the complexity of human genetic disease.
How to Build a Dog
By Evan Ratliff
Photograph by Robert Clark
“In a project called CanMap, a collaboration among Cornell University, UCLA, and the National Institutes of Health, researchers gathered DNA from more than 900 dogs representing 80 breeds, as well as from wild canids such as gray wolves and coyotes. They found that body size, hair length, fur type, nose shape, ear positioning, coat color, and the other traits that together define a breed’s appearance are controlled by somewhere in the neighborhood of 50 genetic switches.”
“The difference between floppy and erect ears is determined by a single gene region in canine chromosome 10, orCFA10. The wrinkled skin of a Chinese shar-pei traces to another region, called HAS2. The patch of ridged fur on Rhodesian ridgebacks? That’s from a change in CFA18. Flip a few switches, and your dachshund becomes a Doberman, at least in appearance. Flip again, and your Doberman is a Dalmatian.”
“Media reports about the gene for red hair, alcoholism, or breast cancer give the false impression that most traits are governed by just one or a few genes. In fact, the Tinkertoy genetics of dog morphology is a complete aberration. In nature, a physical trait or disease state is usually the product of a complex interaction of many genes, each one making a fractional contribution. Height in humans, for instance, is determined by the interaction of some 200 gene regions.”
“So why are dogs so different? The answer, the researchers say, lies in their unusual evolutionary history. Canines were the earliest domesticated animal, a process that started somewhere between 20,000 and 15,000 years ago, most likely when gray wolves began scavenging around human settlements. Dog experts differ on how active a role humans played in the next step, but eventually the relationship became a mutual one, as we began employing dogs for hunting, guarding, and companionship. Sheltered from the survival-of-the-fittest wilderness, those semi-domesticated dogs thrived even though they harbored deleterious genetic mutations—stumpy legs, for instance—that would have been weeded out in smaller wild populations.”
“Thousands of years later, breeders would seize on that diverse raw material when they began creating modern breeds. They tended to grab traits they desired from across multiple breeds—or tried to rapidly replicate mutations in the same one—in order to get the dog they wanted. They also favored novelty, since the more distinct a line of dogs appeared, the more likely it was to garner official recognition as a new breed. Such artificial selection tended to favor single genes with a large impact, allowing traits to be fixed more rapidly than groups of smaller-impact genes ever could.”
“This revelation has implications the scientists are just beginning to unravel—most important, for the understanding of genetic disorders in humans. Already, more than a hundred dog diseases have been mapped to mutations in particular genes, many of them with human counterparts. Those diseases may have a whole array of mutations leading to a risk of disease in dogs, as they do in us. But because dogs have been genetically segregated into breeds developed from just a few original individuals, each breed has a much smaller set of errant genes—often only one or two—underlying the disease.”
“For instance, Cornell researchers studying the degenerative eye disease retinitis pigmentosa—shared by humans and dogs—found 20 different canine genes causing the disorder. But a different gene was the culprit in schnauzers than in poodles, giving researchers some specific leads for where to start looking in humans. Meanwhile a recent study of a rare type of epilepsy in dachshunds found what appears to be a unique genetic signature, which could shed new light on the disorder in us as well.”
“In short, while the Victorian breeders were crafting dogs to suit their tastes, they were also creating genetically isolated populations, little knowing how useful they might be to scientists in the future. The possibilities are especially abundant for cancer, certain types of which can show up as often as 60 percent of the time in some dog breeds but only once in every 10,000 humans.”
“We are the people who are doing the genetics,” says Elaine Ostrander, who studies dog evolution and disease at the National Human Genome Research Institute at NIH. “But breeders are the people who have done all the fieldwork.”
“One category of trait that has so far proved resistant to the CanMap analysis is behavior. Only a single mutant behavioral gene has been identified to date: the dog version of the gene for obsessive-compulsive disorder in humans, which can cause Doberman pinschers to obsessively suck on their fur to the point of bleeding”
“More common characteristics such as loyalty, tenaciousness, or the instinct to herd clearly have genetic underpinnings. But they can also be affected by factors ranging from a dog’s nutrition to the presence of children in the house, making them difficult to quantify rigorously enough to study. Nevertheless, “we’ve probably got as good a shot, if not better, of understanding behavior in dogs over other animals,” says Stanford’s Bustamante. After all, he points out, there are millions of dog lovers out there willing and eager to help with the fieldwork.”